You are in the accessibility menu

Please use this identifier to cite or link to this item:
Controlled transscleral drug delivery formulations to the eye: establishing new concepts and paradigms in ocular anti-inflammatory therapeutics and antibacterial prophylaxis
  • Hosp Olhos Araraquara
  • Universidade Federal de São Paulo (UNIFESP)
  • Univ Araraquara UNIARA
  • Universidade Estadual Paulista (UNESP)
  • Johns Hopkins Univ
  • Univ Calif Irvine
  • Univ Complutense
Importance of the field: The use of topical agents poses unique and challenging hurdles for drug delivery. Topical steroids effectively control ocular inflammation, but are associated with the well-recognized dilemma of patient compliance. Although administration of topical antimicrobials as prophylaxis is acceptable among ophthalmologists, this common practice has no sound evidence base Developing a new antimicrobial agent or delivery strategy with enhanced penetration by considering the anatomical and physiological constraints exerted by the barriers of the eye is not a commonly perceived strategy. Exploiting the permeability of the sclera, subconjunctival routes may offer a promising alternative for enhanced drug delivery and tissue targeting.Area covered in this review: Ocular drug delivery strategies were reviewed for ocular inflammation and infections clinically adopted for newer class of antimicrobials, which use a multipronged approach to limit risks of endophthalmitis.What the reader will gain: The analysis substantiates a new transscleral drug delivery therapeutic approach for cataract surgery.Take home message: A new anti-inflammatory and anti-infective paradigm that frees the patient from the nuisance of topical therapeutics is introduced, opening a large investigative avenue for future improved therapies.
Issue Date: 
Expert Opinion on Drug Delivery. London: Informa Healthcare, v. 7, n. 8, p. 955-965, 2010.
Time Duration: 
Informa Healthcare
  • antibiotics
  • antimicrobials
  • cataract surgery
  • endophthalimitis
  • eye drops
  • eye infections
  • intraocular penetration
  • ocular drug delivery
Access Rights: 
Acesso restrito
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.