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Effects of calcium gluconate and PMSF in the treatment of acute intoxication of chicken by TOCP
Universidade Estadual Paulista (UNESP)
School of Pharmaceutical Sciences UNESP, São Paulo State University
Sponsorship Process Number: 
UNESP: PADC-2005/9-I
To examine the efficacy of calcium gluconate (two doses of Ca-Glu 5 mg/kg i.v.) to alleviate the injurious effects of organophosphorus induced delayed neuropathy (OPIDN) in the presence or absence of phenylmethanesulfonyl fluoride (PMSF go mg/kg i.m.), 14 groups of four isabrown hens were used. To measure the lymphocyte neuropathy target esterase (LNTE)activity, groups receiving just distilled water (control), groups receiving just Tri-orto-cresyl phosphate (TOCP; 500 mg/kg p.o.) (Positive control), and other groups receiving TOCP and Ca-Glu or PMSF simultaneously or 12 hours later following intoxication by TOCP were used. They were sacrificed 12 and 24 hours after the administration of TOCP. To observe a 28-day time course of neurotoxicity scores and calcium plasma concentration, five groups were used. Regarding free Ca(2+)in the plasma, the positive control produced a characteristic profile time course up and down (luring 28 days, and some hens with maximum score of neurotoxicity in 28 days. The treatment, which prevented greater oscillation in free Ca(2+) in the plasma, presented a decrease in OPIDN in relation to the positive control. Twelve hours after the administration of TOCP, LNTE was 70-80% inhibited when compared with control, whereas the first decrease in the free Ca(2+) in the plasma was significantly different from the control only 24 hours after the administration of TOCP. In summary, the sooner the Ca-Glu is started, the less severe the neuropathy effects.
Issue Date: 
Human & Experimental Toxicology. London: Sage Publications Ltd, v. 27, n. 3, p. 247-252, 2008.
Time Duration: 
Sage Publications Ltd
  • calcium gluconate
  • chicken
  • nourophathy target esterase
  • organophasphate-induced delayed neuropathy
  • tri-orto-cresyl phosphate
  • phenylmethanesulfonyl fluoride
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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