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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/unesp/361005
Title: 
Back in mitosis
Author(s): 
Language: 
nau
Description: 
  • Presents video that shows a Xenopus laevis S3 cell reversing cytokinesis and exit from mitosis. The cell is stably expressing GFP alpha-tubulin to visualize dynamics of the microtubule network. This cell was blocked in metaphase with high levels of cyclin B and Cdk1 activity by the addition of the proteasome inhibitor, MG132. Upon treatment with the reversible Cdk inhibitor, Flavopiridol, the cell undergoes cytokinesis without chromosome separation and exits mitosis. Mitotic exit is accompanied by anaphase-like changes in the microtubule network, chromosome decondensation, assembly of the nuclear envelope and formation of a midbody. When the Cdk inhibitor is removed, the midbody recedes and the cleavage furrow re-opens. The mitotic spindle re-forms. The nuclear envelope disassembles. The chromosomes condense and re-align at the metaphase plate
  • Componente Curricular::Educação Superior::Ciências Biológicas::Biologia Geral
Issue Date: 
  • 12-May-2009
  • 12-May-2009
  • Aug-2007
  • 12-May-2009
  • 6-Oct-2008
Publisher: 
The American Society for Cell Biology, ASBC Image & Video Library
Keywords: 
  • Cell
  • Cytokinesis
  • Mitosis
  • Educação Superior::Ciências Biológicas::Biologia Geral
Notes: 
To show a Xenopus laevis S3 cell reversing cytokinesis and exit from mitosi
Credits: 
Duration: 19 s. To visualize this source its necessary the instalation of Quick time. Available at: <http://www.apple.com/pt/quicktime/>
Source: 
http://objetoseducacionais2.mec.gov.br/handle/mec/10250
URI: 
http://acervodigital.unesp.br/handle/unesp/361005
Rights: 
You may use the Images only for research and educational purposes in an educational institution. Images may be stored on a network server, hard drive or removable media, but only while this Agreement remains in effect. All of the Images you use must be accompanied by a notice stating, "© [Date and Author's or Owner's Name]. All rights reserved. Reprinted under license from The American Society for Cell Biology." The notice shall appear with the Images or on a credits page. "Educational purposes" means (i) non-commercial instruction or curriculum based teaching by educators to students at nonprofit educational institutions, (ii) planned non-commercial study, investigation or research directed toward making a contribution to a field of knowledge, or (iii) presentation of research findings at non-commercial peer conferences, workshops or seminars, but in any event there must be express written permission from ASCB before an Image can be published. "Educational institutions" include K-12 schools, colleges and universities. Libraries, museums, hospitals, research institutes and other nonprofit organizations are considered educational institutions when they engage in nonprofit instructional, research or scholarly activities for educational purposes.
Type: 
vídeo
Appears in Collections:MEC - Objetos Educacionais (BIOE) - OE

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