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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/unesp/361052
Title: 
No waiting for anaphase [1d. First place]
Author(s): 
Language: 
nau
Description: 
  • This HeLa cell, which is expressing both a kinetochore marker (EGFP-CENP-B) and a centrosome marker (Venus-centrin), has been depleted of the spindle assembly checkpoint protein Mad2. In the absence of Mad2, the cell rapidly progresses from early prometaphase through anaphase and cytokinesis. The spindle assembly checkpoint functions to generate a WAIT signal until all sister kinetochore pairs become properly attached to the mitotic spindle. Loss of checkpoint function leads to anaphase initiation before kinetochores are completely aligned at the spindle equator. Despite the rapid nature of these divisions, the majority of the kinetochores appear to separate properly in Mad2-depleted cells. However, at least a few lagging chromosomes are frequently observed in these cells, demonstrating the importance of checkpoint function. Note that the frame width is approximately 30 microns
  • Componente Curricular::Educação Superior::Ciências Biológicas::Biologia Geral
Issue Date: 
  • 12-May-2009
  • 12-May-2009
  • 18-Feb-2007
  • 12-May-2009
  • 6-Oct-2008
Publisher: 
The American Society for Cell Biology, ASCB Image & Video Library
Keywords: 
  • Cell biology
  • Kinetochore
  • Microtubule
  • Mitosis
  • Mitotic spindle
  • Educação Superior::Ciências Biológicas::Biologia Geral
Notes: 
To show the no waiting for anaphase
Credits: 
Duration: 10 s. Contributors: Mike Wagenbach (University of Washington, Seattle, WA) and Benjamin Major (University of Washington, Seattle, WA). This video was categorized by the site as: [Celldance 2007: 1d. First place]. Software required: Apple Quicktime 7 player. Available at: <http://www.apple.com/quicktime/download/win.html>
Source: 
http://objetoseducacionais2.mec.gov.br/handle/mec/10256
URI: 
http://acervodigital.unesp.br/handle/unesp/361052
Rights: 
You may use the Images only for research and educational purposes in an educational institution. Images may be stored on a network server, hard drive or removable media, but only while this Agreement remains in effect. All of the Images you use must be accompanied by a notice stating, "© [Date and Author's or Owner's Name]. All rights reserved. Reprinted under license from The American Society for Cell Biology." The notice shall appear with the Images or on a credits page. "Educational purposes" means (i) non-commercial instruction or curriculum based teaching by educators to students at nonprofit educational institutions, (ii) planned non-commercial study, investigation or research directed toward making a contribution to a field of knowledge, or (iii) presentation of research findings at non-commercial peer conferences, workshops or seminars, but in any event there must be express written permission from ASCB before an Image can be published. "Educational institutions" include K-12 schools, colleges and universities. Libraries, museums, hospitals, research institutes and other nonprofit organizations are considered educational institutions when they engage in nonprofit instructional, research or scholarly activities for educational purposes.
Type: 
vídeo
Appears in Collections:MEC - Objetos Educacionais (BIOE) - OE

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