You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/112298
Title: 
Insights on the HLA-G Evolutionary History Provided by a Nearby Alu Insertion
Author(s): 
Institution: 
  • Universidade Federal de Goiás (UFG)
  • Universidade de São Paulo (USP)
  • Universidade de Brasília (UnB)
  • Univ Paris 04
  • Univ Paris 05
  • Hop St Louis
  • Univ Paris Diderot
  • Universidade Estadual Paulista (UNESP)
ISSN: 
0737-4038
Sponsorship: 
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Sponsorship Process Number: 
CNPq: 470873/2011-6
Abstract: 
The AluyHG element belongs to the AluYb8 subfamily. It is a polymorphic insertion, located approximately 20 kb from the HLA-G 3'-untranslated region (3'-UTR), which has been used for evolution studies because it exhibits identity for descendants and it is still polymorphic in the human genome. To understand the evolutionary mechanisms acting on HLA-G, we evaluated the presence or absence of the AluyHG element, associating this variable site with others observed at HLA-G coding, 3'-UTR, or both regions in four distinct populations (Brazilian, French, Congolese, and Senegalese). The results were compared with the 1000Genomes Consortium data. The worldwide AluyHG frequencies showed an increment, starting lower in Africa and increasing following distance and time of human dispersion out of Africa. The same haplotype pattern was observed in all populations, indicating that most of the HLA-G haplotypes already detected were originated earlier in Africa, before Homo sapiens dispersion. The AluyHG insertion was associated with the G*01:01:01:01/UTR-1 haplotype, with rare recombinants. Despite its high frequency in worldwide populations, the G*01:01:01:01/UTR-1 haplotype should be very recent. The low frequency of recombinants indicates that the rate of recombination at the HLA-G gene is very low.
Issue Date: 
1-Nov-2013
Citation: 
Molecular Biology And Evolution. Oxford: Oxford Univ Press, v. 30, n. 11, p. 2423-2434, 2013.
Time Duration: 
2423-2434
Publisher: 
Oxford University Press
Keywords: 
  • AluyHG
  • HLA-G
  • 3'-untranslated region
  • haplotypes
  • worldwide diversity
  • human evolution
Source: 
http://dx.doi.org/10.1093/molbev/mst142
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/112298
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.