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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/112302
Title: 
Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0278-6915
Sponsorship: 
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Sponsorship Process Number: 
  • FAPESP: 08/50985-5
  • FAPESP: 07/54858-5
  • FAPESP: 09/50890-7
  • CNPq: 474572/2008-0
  • CNPq: 301585/2009-1
Abstract: 
Coffee has been inversely related to the incidence of human liver disease; however, whether caffeine is the component responsible for the beneficial effects of coffee remains controversial. This study evaluated the beneficial effects of coffee or caffeine in a medium-term bioassay for rat liver fibrosis/carcinogenesis induced by diethylnitrosamine (DEN) and carbon tetrachloride (CCl4). One week after the DEN injection, the groups started to receive conventional coffee, instant coffee or 0.1% caffeine ad libitum for 24 weeks. The groups receiving conventional coffee or caffeine presented a significant reduction in collagen content and mRNA expression of collagen I. The groups receiving instant coffee or caffeine had a significant reduction in the size and area of pre-neoplastic lesions and in the mean number of neoplastic lesions. A significant increase in liver bax protein levels was observed in the groups receiving instant coffee or caffeine as compared to the control group. These data indicate that the most pronounced hepatoprotective effect against fibrosis was observed in the groups receiving conventional coffee and 0.1% caffeine, and the greatest effects against liver carcinogenesis were detected in the groups receiving instant coffee and 0.1% caffeine. (C) 2013 Elsevier Ltd. All rights reserved.
Issue Date: 
1-Feb-2014
Citation: 
Food And Chemical Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 64, p. 20-26, 2014.
Time Duration: 
20-26
Publisher: 
Elsevier B.V.
Keywords: 
  • Coffee beverages
  • Caffeine
  • Liver fibrosis and carcinogenesis
  • Prevention
Source: 
http://dx.doi.org/10.1016/j.fct.2013.11.011
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/112302
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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