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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/112305
Title: 
Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework
Author(s): 
Institution: 
  • Univ Nebraska Med Ctr
  • Universidade Estadual Paulista (UNESP)
  • BASF
ISSN: 
1040-8444
Sponsorship: 
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
  • Center for Evaluation of The Impact of the Environment on Human Health (TOXICAM)
  • UNESP
  • University of Nebraska Medical Center
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
  • Brazilian Ministry of Education (MEC)
Sponsorship Process Number: 
  • FAPESP: 06/60506-1
  • FAPESP: 09/02754-7
  • CNPq: 472330/07-1
Abstract: 
Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of kidney pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year bioassay. Diuron is registered for both occupational and residential uses and is used worldwide for more than 30 different crops. The proposed rat urothelial mode of action (MOA) for this herbicide consists of metabolic activation to metabolites that are excreted and concentrated in the urine, leading to cytotoxicity, urothelial cell necrosis and exfoliation, regenerative hyperplasia, and eventually tumors. We show evidence for this MOA for diuron using the International Programme on Chemical Safety (IPCS) conceptual framework for evaluating an MOA for chemical carcinogens, and the United States Environmental Protection Agency (USEPA) and IPCS framework for assessing human relevance.
Issue Date: 
1-May-2014
Citation: 
Critical Reviews In Toxicology. London: Informa Healthcare, v. 44, n. 5, p. 393-406, 2014.
Time Duration: 
393-406
Publisher: 
Informa Healthcare
Keywords: 
  • bladder cancer
  • cell proliferation
  • cytotoxicity
  • diuron
  • metabolites
  • hyperplasia
  • urothelium
Source: 
http://dx.doi.org/10.3109/10408444.2013.877870
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/112305
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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