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http://acervodigital.unesp.br/handle/11449/112305
- Title:
- Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework
- Univ Nebraska Med Ctr
- Universidade Estadual Paulista (UNESP)
- BASF
- 1040-8444
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Center for Evaluation of The Impact of the Environment on Human Health (TOXICAM)
- UNESP
- University of Nebraska Medical Center
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- Brazilian Ministry of Education (MEC)
- FAPESP: 06/60506-1
- FAPESP: 09/02754-7
- CNPq: 472330/07-1
- Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of kidney pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year bioassay. Diuron is registered for both occupational and residential uses and is used worldwide for more than 30 different crops. The proposed rat urothelial mode of action (MOA) for this herbicide consists of metabolic activation to metabolites that are excreted and concentrated in the urine, leading to cytotoxicity, urothelial cell necrosis and exfoliation, regenerative hyperplasia, and eventually tumors. We show evidence for this MOA for diuron using the International Programme on Chemical Safety (IPCS) conceptual framework for evaluating an MOA for chemical carcinogens, and the United States Environmental Protection Agency (USEPA) and IPCS framework for assessing human relevance.
- 1-May-2014
- Critical Reviews In Toxicology. London: Informa Healthcare, v. 44, n. 5, p. 393-406, 2014.
- 393-406
- Informa Healthcare
- bladder cancer
- cell proliferation
- cytotoxicity
- diuron
- metabolites
- hyperplasia
- urothelium
- http://dx.doi.org/10.3109/10408444.2013.877870
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/112305
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