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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/112310
Title: 
Cervicovaginal Levels of Proinflammatory Cytokines Are Increased During Chlamydial Infection in Bacterial Vaginosis But Not in Lactobacilli-Dominated Flora
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Universidade Estadual de Campinas (UNICAMP)
  • Univ Hosp Gasthuisberg
ISSN: 
1089-2591
Sponsorship: 
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Sponsorship Process Number: 
  • FAPESP: 08/55420-6
  • FAPESP: 09/50560-7
  • CAPES: 1179-09-8
Abstract: 
Objective. The purpose of this study was to assess the cervicovaginal levels of proinflammatory cytokines in women with Chlamydia trachomatis (CT) infection in the presence of bacterial vaginosis (BV) and normal flora and to compare with those negative for CT.Materials and Methods. In this cross-sectional study, nonpregnant women were enrolled at 2 outpatient clinics and at 1 primary medical care unit in Sao Paulo State, Brazil. Cervicovaginal samples from 256 women with BV, of which 68 (26.6%) had concomitant CT infection and 188 (73.4%) were CT-negative, were measured for interleukin-1 beta (IL-1 beta), IL-6, and IL-8 by enzyme-linked immunosorbent assay. A matching number of samples from women with normal flora, CT-positive (n = 68) and negative (n = 188), were evaluated as control. Cytokine levels were compared by Mann-Whitney test and differences were considered significant at p < .05.Results. In CT-negative women, IL-1 beta was increased in BV (p < .001) when compared to normal flora, while the levels of IL-6 and IL8 were unchanged. The presence of CT infection was not associated with differences on cytokine levels in women with normal flora. However, women with BV had higher levels of IL-1 beta (p = .02), IL-6 (p = .02), and IL-8 (p = .03) in the presence of CT when compared to those who tested negative for CT.Conclusions. Detection of endocervical CT is associated with increased cervicovaginal IL-1 beta, IL-6, and IL-8 levels in women with concomitant BV but not in those with normal flora.
Issue Date: 
1-Jul-2014
Citation: 
Journal of Lower Genital Tract Disease. Philadelphia: Lippincott Williams & Wilkins, v. 18, n. 3, p. 261-265, 2014.
Time Duration: 
261-265
Publisher: 
Lippincott Williams & Wilkins
Keywords: 
  • bacterial vaginosis
  • Chlamydia trachomatis
  • endocervicitis
  • cytokine
Source: 
http://dx.doi.org/10.1097/LGT.0000000000000003
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/112310
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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