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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/112621
Title: 
Geraniol-a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Universidade Federal da Paraíba (UFPB)
ISSN: 
0028-1298
Sponsorship: 
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Abstract: 
Geraniol is an acyclic monoterpene alcohol commonly used as a flavoring agent. The present study was undertaken to investigate antiulcerogenic effects of geraniol and to determine the possible mechanisms involved in this action. In the model of the ethanol-induced ulcer, treatment of rats with geraniol by oral route significantly inhibited gastric lesions by 70 % (7.50 mg/kg) to 99 % (200 mg/kg). Analysis of the gastric tissue of rats treated with geraniol (7.50 mg/kg) revealed that total glutathione content levels (GSH) increased and levels of myeloperoxidase (MPO) decreased in the gastric mucosa. Oral treatment with geraniol significantly decreased the number of ulcerative lesions induced by ischemia/reperfusion injury by 71 % and the duodenal ulcers induced by cysteamine by 68 %. The action of geraniol was mediated by the activation of defensive mucosa-protective factors such as the nitric oxide (NO) pathway, endogenous prostaglandins, increased mucus production, increased sulfhydryl compounds, antioxidant properties and the stimulation of calcitonin gene-related peptide (CGRP) release through the activation of transient receptor potential vanilloid (TRPV). The multifaceted gastroprotective mechanisms of geraniol represent a promising option for the treatment of gastric and duodenal mucosa injury.
Issue Date: 
1-Apr-2014
Citation: 
Naunyn-schmiedebergs Archives Of Pharmacology. New York: Springer, v. 387, n. 4, p. 355-365, 2014.
Time Duration: 
355-365
Publisher: 
Springer
Keywords: 
  • Geraniol
  • Monoterpene
  • Gastric ulcer
  • Duodenal ulcer
  • Multifunctional effects
Source: 
http://dx.doi.org/10.1007/s00210-013-0947-z
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/112621
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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