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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/116632
Title: 
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine
Author(s): 
Institution: 
  • Univ Nacl Cordoba
  • Universidade Estadual Paulista (UNESP)
ISSN: 
0731-7085
Sponsorship: 
  • Fondo para la Investigacion Cientifica y Tecnologica (FONCYT)
  • Consejo Nacional de Investigaciones Cientificas y Tecnicas" (CONICET)
  • Secretaria de Ciencia y Tecnica de la Universidad Nacional de Cordoba (SECyT-UNC)
Sponsorship Process Number: 
  • FONCYT: BID1728/OC-AR PICT 1376
  • CONICET: 112 201001 00215
  • SECyT-UNC: Resolucion: 162/12
Abstract: 
This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with beta-(beta CD), methyl-(M beta CD) and hydroxypropyl-P-cyclodextrin (HP beta CD) using meglumine (MEG) as the ternary component. The combination of MEG with M beta CD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and M beta CD or HP beta CD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and M beta CD or HP beta CD in the ternary lyophilized systems. The ternary complexes with beta CD and M beta CD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation. (C) 2014 Elsevier B.V. All rights reserved.
Issue Date: 
1-Nov-2014
Citation: 
Journal Of Pharmaceutical And Biomedical Analysis. Amsterdam: Elsevier Science Bv, v. 100, p. 64-73, 2014.
Time Duration: 
64-73
Publisher: 
Elsevier B.V.
Keywords: 
  • Sulfamerazine
  • Cyclodextrin
  • Ternary complex
  • Solubility
  • In vitro-release
Source: 
http://dx.doi.org/10.1016/j.jpba.2014.07.008
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/116632
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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