A synthesis of captopril through a Baylis-Hillman reaction

Feltrin, M. P.; Almeida, W. P.

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/116965

Title:

A synthesis of captopril through a Baylis-Hillman reaction

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)

ISSN:

0039-7911

Abstract:

A synthesis of the antihipertensive amide 1, named captopril, is described. The strategy is based on a Baylis-Hillman reaction between N-acryloylproline and formaldehyde. Subsequential diastereoselective hydrogenation step and functional group interconversion provided captopril in good overall yield.

Issue Date:

1-Jan-2003

Citation:

Synthetic Communications. New York: Marcel Dekker Inc, v. 33, n. 7, p. 1141-1146, 2003.

Time Duration:

1141-1146

Publisher:

Marcel Dekker Inc

Source:

http://dx.doi.org/10.1081/SCC-120017189

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/116965

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