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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/117560
Título: 
Evaluation of the antimutagenic activity and mode of action of the fructooligosaccharide inulin in the meristematic cells of Allium cepa culture
Autor(es): 
Instituição: 
  • Universidade Federal de Mato Grosso do Sul (UFMS)
  • Universidade Estadual Paulista (UNESP)
  • Universidade Estadual de Londrina (UEL)
ISSN: 
1676-5680
Financiador: 
  • FUNDECT
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento: 
  • FUNDECT5/2011
  • FUNDECT23/200.702/2012
  • FUNDECT0207/12
  • FUNDECT08/2009
  • FUNDECT15411.285.865.22102009
  • CNPq: 06/2011
  • CNPq: PRONEM
Resumo: 
This study evaluated the mutagenicity and antimutagenicity of inulin in a chromosomal aberration assay in cultures of the meristematic cells of Allium cepa. The treatments evaluated were as follows: negative control - seed germination in distilled water; positive control - aqueous solution of methyl methanesulfonate (10 mu g/mL MMS); mutagenicity - aqueous solutions of inulin (0.015, 0.15, and 1.50 mu g/mL); and antimutagenicity - associations between MMS and the different inulin concentrations. The antimutagenicity protocols established were pretreatment, simultaneous simple, simultaneous with pre-incubation, and post-treatment. The damage reduction percentage (DR%) was 43.56, 27.77, and 55.92% for the pre-treatment; -31.11, 18.51, and 7.03% for the simultaneous simple; 30.43, 19.12, and 21.11% for the simultaneous with pre-incubation; and 64.07, 42.96, and 53.70% for the post-treatment. The results indicated that the most effective treatment for inhibiting damages caused by MMS was the post-treatment, which was followed by the pretreatment, suggesting activity by bioantimutagenesis and desmutagenesis. The Allium cepa assay was demonstrated to be a good screening test for this type of activity because it is easy to perform, has a low cost, and shows DR% that is comparable to that reported studies that evaluated the prevention of DNA damage in mammals by inulin.
Data de publicação: 
1-Jan-2014
Citação: 
Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 13, n. 3, p. 4808-4819, 2014.
Duração: 
4808-4819
Publicador: 
Funpec-editora
Palavras-chaves: 
  • Inulin
  • Fiber
  • Antimutagenic activity
Fonte: 
http://dx.doi.org/10.4238/2014.February.14.14
Endereço permanente: 
Direitos de acesso: 
Acesso aberto
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/117560
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