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http://acervodigital.unesp.br/handle/11449/11801- Title:
- Polymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Cancer
- Universidade Estadual de Londrina (UEL)
- Londrina Hosp Canc
- Hlth Sci Ctr
- Universidade Estadual Paulista (UNESP)
- 0735-7907
- Fundação Araucária de Apoio ao Desenvolvimento Científico e Tecnológico do Paraná (FAADCT/PR)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- The study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06-2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21-2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.
- 1-Nov-2010
- Cancer Investigation. Philadelphia: Taylor & Francis Inc, v. 28, n. 9, p. 917-924, 2010.
- 917-924
- Taylor & Francis Inc
- AR gene
- Gleason score
- Histopathological parameters
- Polymorphisms
- Prostate Cancer
- PSA gene
- http://dx.doi.org/10.3109/07357907.2010.483509
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/11801
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