Using the comet and micronucleus assays for genotoxicity studies: a review

Araldi, Rodrigo Pinheiro; Melo, Thatiana Corrêa de; Mendes, Thais Biude; De Sá Júnior, Paulo; Nozima, Bruno Heidi Nakano; Ito, Eliana Tiemi; Carvalho, Rodrigo Franco de; Souza, Edislane Barreiros de; Stocco, Rita de Cassia

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/127163

Title:

Using the comet and micronucleus assays for genotoxicity studies: a review

Author(s):

Institution:

Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)
Universidade Federal de São Paulo (UNIFESP)

ISSN:

0753-3322

Abstract:

Physical, chemical and biological agents can act in the DNA, resulting in mutation involved in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate potential risk of cancer. Among these tests, the comet assay (CA) and micronucleus assay (MNA) are the most commonly used. However, there are different protocols and recommendations already published. This is the first review, after the inclusion of CA in S2R1 guidance and OECD 489, which summarizes the main technical recommendations of both CA and MNA.

Issue Date:

2015

Citation:

Biomedicine & Pharmacotherapy, v. 72, p. 74-82, 2015.

Time Duration:

74-82

Keywords:

Genotoxicity tests
Comet assay
Micronucleus assay
Mutagenesis

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/127163

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