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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/128425
Title: 
Evidence of epithelial-mesenchymal transition in canine prostate cancer metastasis
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0034-5288
Sponsorship: 
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Sponsorship Process Number: 
  • FAPESP: 2010/13774-6
  • FAPESP: 2012/16426-1
  • FAPESP: 2012/16068-0
Abstract: 
The epithelial mesenchymal transition (EMT) is a fundamental event responsible for the invasiveness and metastasis of epithelial tumours. The EMT has been described in many human cancers, but there are few reports of this phenomenon in veterinary oncology. Due to the importance of this process, the current study evaluated mesenchymal and epithelial marker protein expression in prostate lesions from dogs. Our results indicate both a loss of E-cadherin and translocation of P-catenin from the membrane to the cytoplasm and nucleus in the tumour group. Vimentin expression in the tumour group was higher than in normal tissue. All of the metastases were positive for prostate-specific antigen, pan-cytokeratin and E-cadherin, although fewer positive cells were present than in the primary tumours. The immunohistochemical results showed a loss of epithelial markers and a gain of a mesenchymal marker among metastatic cells, suggesting that the EMT occurs during the metastatic process of canine prostate carcinoma. (C) 2015 Elsevier Ltd. All rights reserved.
Issue Date: 
1-Jun-2015
Citation: 
Research In Veterinary Science. Oxford: Elsevier Sci Ltd, v. 100, p. 176-181, 2015.
Time Duration: 
176-181
Publisher: 
Elsevier B.V.
Keywords: 
  • Dog
  • Prostate cancer
  • Immunohistochemistry
  • Epithelial-mesenchymal crosstalk
Source: 
http://www.sciencedirect.com/science/article/pii/S0034528815000557
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/128425
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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