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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/128577
Title: 
Enhancing the versatility of alternate current biosusceptometry (ACB) through the synthesis of a dextrose-modified tracer and a magnetic muco-adhesive cellulose gel
Author(s): 
Institution: 
  • Univ Copenhagen
  • Universidade Estadual Paulista (UNESP)
ISSN: 
0928-4931
Sponsorship: 
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Science Without Borders Program
Sponsorship Process Number: 
  • FAPESP: 2010/07639-9
  • Science Without Borders Program: 246604/2012-3
Abstract: 
Alternate Current Biosusceptometry (ACB) is a promising bio-magnetic method, radiation free and easily performed used for gastric emptying exams. Due to development on its sensitivity level, interesting nature, noninvasiveness and low cost it has attracted a lot of attention. In this work, magnetic nanoparticles of Mn-Zn ferrite as well as dextrose-modified nanoparticles were synthesized to be used as possible tracers in ACB gastric emptying exams. In addition, a magnetic muco-adhesive gel was obtained by modifying the ferrite nanoparticles with cellulose. Based on in-vivo tests in rats, we show that the pure ferrite nanoparticles, whose isoelectric point was found to be at pH = 3.2, present a great sensitivity to pH variations along the gastrointestinal tract, while the reduction of the isoelectric point by the dextrose modification leads to suitable nanoparticles for rapid gastric emptying examinations. On the other hand, the in-vivo tests show that the muco-adhesive cellulose gel presents substantial stomach adhesion and is a potential drug delivery system easily traceable by the ACB system. (C) 2014 Elsevier B.V. All rights reserved.
Issue Date: 
1-Mar-2015
Citation: 
Materials Science &engineering C-materials For Biological Applications, v. 48, p. 80-85, 2015.
Time Duration: 
80-85
Publisher: 
Elsevier B.V.
Keywords: 
  • Alternate current biosusceptometry
  • Gastric emptying
  • Bio-magnetic materials
  • Muco-adhesive gel
  • Cellulose
  • Dextrose
Source: 
http://www.sciencedirect.com/science/article/pii/S0928493114007838
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/128577
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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