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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/129720
Title: 
Antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of aggressive periodontitis: a split-mouth randomized controlled trial
Author(s): 
Institution: 
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
  • Universidade Estadual de Campinas (UNICAMP)
ISSN: 
0022-3492
Abstract: 
Background: The management of aggressive periodontitis (AgP) represents a challenge for clinicians because there are no standardized protocols for an efficient control of the disease. This randomized controlled clinical trial evaluated the effects of repeated applications of antimicrobial photodynamic therapy (aPDT) adjunctive to scaling and root planing (SRP) in patients with AgP. Methods: Using a split-mouth design, 20 patients with generalized AgP were treated with aPDT + SRP (test group) or SRP only (control group). aPDT was applied at four periods. All patients were monitored for 90 days. Clinical, microbiologic, and immunologic parameters were statistically analyzed. Results: In deep periodontal pocket analysis (probing depth [PD] >= 7 mm at baseline), the test group presented a decrease in PD and a clinical attachment gain significantly higher than the control group at 90 days (P < 0.05). The test group also demonstrated significantly less periodontal pathogens of red and orange complexes and a lower interleukin-1 beta/interleukin-10 ratio than the control group (P < 0.05). Conclusion: The application of four sessions of aPDT, adjunctive to SRP, promotes additional clinical, microbiologic, and immunologic benefits in the treatment of deep periodontal pockets in single-rooted teeth in patients with AgP.
Issue Date: 
1-Mar-2015
Citation: 
Journal Of Periodontology. Chicago: Amer Acad Periodontology, v. 86, n. 3, p. 376-386, 2015.
Time Duration: 
376-386
Publisher: 
Amer Acad Periodontology
Keywords: 
  • Aggressive periodontitis
  • Cytokines
  • Microbiology
  • Photochemotherapy
  • Photosensitizing agents
Source: 
http://www.joponline.org/doi/abs/10.1902/jop.2014.140392
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/129720
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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