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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/12991
Título: 
Genotoxicity in primary human peripheral lymphocytes after exposure to radiopacifiers in vitro
Autor(es): 
Instituição: 
  • Universidade Federal de São Paulo (UNIFESP)
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
ISSN: 
0957-4530
Resumo: 
Taking into consideration that DNA damage plays an important role in carcinogenesis, the purpose of this study was to evaluate whether some radiopacifiers widely used in clinical practice are able to induce genetic damage in primary human cells in vitro. Human peripheral lymphocytes obtained from 10 healthy volunteers were exposed to barium sulphate (BaSO(4)), zirconium oxide (ZnO(2)) and bismuth oxide (Bi(2)O(3)) at final concentrations ranging from 1 to 1000 mu g/mL for 1 h at 37 degrees C. The negative control group was treated with vehicle control (phosphate buffer solution) for 1 h at 37 degrees C and the positive control group was treated with hydrogen peroxide (at 100 mu M) for 5 min on ice. Results were analyzed by the Friedman non-parametric test. The results pointed all compounds tested out did not induce DNA breakage in human peripheral lymphocytes as depicted by the mean tail moment and tail intensity in all concentrations tested. In summary, our results indicate that exposure to these radiopacifiers may not be a factor that increases the level of DNA lesions in human peripheral lymphocytes as detected by single cell gel (comet) assay.
Data de publicação: 
1-Fev-2008
Citação: 
Journal of Materials Science-materials In Medicine. Dordrecht: Springer, v. 19, n. 2, p. 601-605, 2008.
Duração: 
601-605
Publicador: 
Springer
Fonte: 
http://dx.doi.org/10.1007/s10856-007-3000-2
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/12991
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