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http://acervodigital.unesp.br/handle/11449/130784
- Title:
- Charge effect in the interaction of doxorubicin and derivatives with polydeoxynucleotides
- Universidade Estadual Paulista (UNESP)
- 0006-3002
- The equilibrium interaction of doxorubicin and its N-acetyl derivative with a series of purine-pyrimidine alternating polydeoxynucleotides has been studied through spectrofluorometry to assess the relevance of the electrostatic contribution to DNA intercalation. The results have shown that: (a) the suppression of the positive charge on the aminosugar has: (I) a profound negative effect on the free energy of intercalation, as expected, and (II) a negligible influence on the base specificity, which supports the notion of an essentially electrostatic effect of N-acetylation on intercalation; (b) a reasonably good accord with the demands of a polyelectrolytic model, due to Friedman and Manning, is found.
- 11-Feb-1992
- Biochimica Et Biophysica Acta, v. 1129, n. 3, p. 294-302, 1992.
- 294-302
- http://www.ncbi.nlm.nih.gov/pubmed/1536881
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/130784
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