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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/131177
Title: 
Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma
Author(s): 
Institution: 
  • Universidade Federal de Santa Maria (UFSM)
  • Universidade Estadual Paulista (UNESP)
  • Universidade de Franca (UNIFRAN)
  • Universidade do Oeste de Santa Catarina (UNOESC)
  • Universidade Luterana do Brasil
  • Universidade do Estado de Santa Catarina (UDESC)
ISSN: 
1618-0631
Sponsorship: 
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Sponsorship Process Number: 
  • FAPESP: 2011/08416-6
  • FAPESP: 2011/11355-9
Abstract: 
Mammary carcinoma is the most common cancer that affects dogs, and in many cases it leads to death. Thus, given the importance of this disease, to clarify its pathogenesis is an important measure. In this sense, the aim of this study was to investigate the levels of cytokines and nitric oxide (NO), oxidative and antioxidant status, as well as the activity of adenosine deaminase (ADA) and butyrylcholinesterase (BChE) in dogs diagnosed with mammary carcinoma. With this purpose, thirty-three (33) serum samples from female dogs with histopathological diagnosis of mammary carcinoma, without evidence of metastasis, were used (group B). The material was classified based on the degree of malignancy, as follows: subgroup B1 (low-grade malignancy; n=26) and subgroup B2 (high grade of malignancy; n=7). Serum samples from healthy females (group A; n=10) were used as negative control. Our results showed that levels of cytokines (TNF-α, INF-γ, IL-1, and IL-6), NOx (nitrite/nitrate), AOPP (protein oxidation), and FRAP (antioxidant power) were significantly (P<0.05) increased in dogs with mammary carcinoma (group B), when compared with group A. On the other hand, ADA activity was significantly decreased (P<0.05) in both subgroups B1 and B2, when compared with group A. BChE activity, however, was reduced (P<0.05) only in subgroup B2 when compared with group A and subgroup B1. Unlike other variables, NO, AOPP, and IFN-γ were influenced by the degree of tumor malignancy, i.e., their levels were even higher in subgroup B2. Therefore, based on these results, we can conclude that all variables investigated are related to the pathogenesis of this disease, since they were altered in dogs with mammary tumor. Additionally, we suggest that ADA activity had an anti-inflammatory effect on these tumor samples, probably in order to modulate the inflammatory response.
Issue Date: 
2015
Citation: 
Pathology, Research And Practice, v. 211, n. 9, p. 677-681, 2015.
Time Duration: 
677-681
Publisher: 
Elsevier B. V.
Keywords: 
  • Breast cancer
  • Immune response
  • Oxidative stress
  • Pathogenesis
Source: 
http://dx.doi.org/10.1016/j.prp.2015.06.011
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/131177
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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