You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/132337
Title: 
Role of the medial septal area on the cardiovascular, fluid and electrolytic responses to angiotensin II and cholinergic activation into the subfornical organ in rats
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0361-9230
Abstract: 
In the present study we investigated the effect of electrolytic lesion of the medial septal area (MSA) on the pressor and dipsogenic response to cholinergic activation and angiotensin II (ANGII) injection into the subfornical organ (SFO) in rats. In addition the effect of MSA lesion on the natriuresis, kaliuresis and diuresis after cholinergic activation of the SFO was also investigated. Sham- and MSA-lesioned rats with a stainless steel cannula implanted into the SFO was used. The injection of ANGII (12 ng) into the SFO in sham rats produced pressor (24 ± 2 mmHg) and dipsogenic (9.6 ± 1.1 ml/h) responses. MSA lesion, both acute (2-6 days) and chronic (15-19 days), reduced the pressor (14 ± 2 mmHg) and dipsogenic (2.7 ± 1 ml/h) responses to ANGII into SFO. The injection of the cholinergic agonist carbachol (2 nmol) into the SFO in sham rats produced pressor (48 ± 4 mmHg), dipsogenic (10 ± 1.2 ml/h), natriuretic (457 ± 58 μEq/2 h) and kaliuretic (249 ± 16 μEq/2 h) responses. Acute, but not chronic MSA lesion reduced the pressor (27 ± 3 mmHg), natriuretic (198 ± 55 μEq/2 h) and kaliuretic (128 ± 16 μEq/2 h) responses to carbachol into SFO. No change in the dipsogenic response to carbachol into the SFO was observed in MSA-lesioned rats. Antidiuresis after carbachol was observed only in MSA-lesioned rats. The present results show that the MSA plays a role on the pressor, natriuretic and kaliuretic responses to cholinergic activation of the SFO in rats and on the pressor and dipsogenic responses to ANGII into the same area. In addition, they provide circumstancial evidence for separate circuits subserving the dipsogenic response to central cholinergic and angiotensinergic activation. A facilited diuresis after MSA lesion is also suggested.
Issue Date: 
1-Jan-1994
Citation: 
Brain Research Bulletin, v. 33, n. 3, p. 249-254, 1994.
Time Duration: 
249-254
Keywords: 
  • Angiotensin II
  • Arterial pressure
  • Natriuresis
  • Septal area
  • Subfornical organ
  • Water intake
  • Angiotensin
  • Animal experiment
  • Antidiuresis
  • Cholinergic stimulation
  • Controlled study
  • Fluid intake
  • Kaliuresis
  • Male
  • Natriuresis
  • Nonhuman
  • Pressor response
  • Priority journal
  • Rat
  • Septum pellucidum
  • Subfornical organ
  • Thirst
  • Animal
  • Blood Pressure
  • Carbachol
  • Diuresis
  • Drinking
  • Injections
  • Male
  • Parasympathetic Nervous System
  • Potassium
  • Rats
  • Rats, Inbred Strains
  • Septum Pellucidum
  • Subfornical Organ
  • Support, Non-U.S. Gov't
Source: 
http://dx.doi.org/10.1016/0361-9230(94)90191-0
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/132337
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.