Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates

Santos, Juliana Alves dos; Corrales, Roberta Cristina Novaes Reis; Pavan, Fernando Rogério; Leite, Clarice Queico Fujimura; Dias, Rafael Mafra de Paula; Silva, Adilson David da

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/133718

Title:

Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
Universidade Federal de Juiz de Fora (UFJF)

ISSN:

2028-3997

Sponsorship:

Coordenação de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Sponsorship Process Number:

FAPESP: 2008/10390-2
FAPESP: 2009/06499-1

Abstract:

We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.

Issue Date:

2012

Citation:

Mediterranean Journal of Chemistry, v. 1, n. 6, p. 281-288, 2012.

Time Duration:

281-288

Keywords:

Carbohydrate
Glycoconjugates
1,2,3-triazole
Antitubercular activity

Source:

http://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15

URI:

Access Rights:

Acesso aberto

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/133718

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