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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/133745
Title: 
Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
2155-9872
Abstract: 
Sodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.
Issue Date: 
2013
Citation: 
Journal of Analytical & Bioanalytical Techniques, v. 5, n. 1, p. 1-6, 2013.
Time Duration: 
1-6
Keywords: 
  • Malignant hyperthermia
  • Sodium azumolene
  • UV-VIS
  • Spectrophotometry
  • Liquid chromatography
  • Quality control
Source: 
http://dx.doi.org/10.4172/2155-9872.1000177
URI: 
Access Rights: 
Acesso aberto
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/133745
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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