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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/133817
Title: 
Leishmanicidal activity of different parts from Arrabidaea brachypoda (DC.) Bureau (Bignoniaceae)
Author(s): 
Institution: 
  • Universidade Vale do Rio Verde (UNINCOR)
  • Universidade Estadual Paulista (UNESP)
  • Universidade Federal de Alfenas (UNIFAL)
ISSN: 
1517-0276
Abstract: 
Infections by protozoans of the genus Leishmania are the major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials, which exert renal and cardiac toxicity. Thus, there is a strong need for safer and more effective treatments against leishmaniasis. The present study was designated to evaluate, by a bioguided assay, the leishmanicidal activity of hidro-ethanolic extracts from different parts (leves, caule and root) of one same plant the Arrabidaea brachypoda (DC.) Bureau. Its has been used to relieve general pain, painful joints and kidney stones in Brazilian folk medicine. Nevertheless, scientific information regarding this species is scarce; there are no reports related to its possible leishmanicidal activity. The leves extract presented the best activity on promastigotes forms of Leishmania (L.) amazonensis, when compared to the other extracts. It showed significant activity on Leishmania (L.) amazonensis. Our results are promising, showing that these compounds are biologically active on Leishmania (L.) amazonensis.
Issue Date: 
2012
Citation: 
Revista da Universidade Vale do Rio Verde, v. 10, n. 1, p. 49-55, 2012.
Time Duration: 
49-55
Keywords: 
  • Arrabidaea brachypoda
  • Leishmania
  • Promastigotes
Source: 
http://dx.doi.org/10.5892/ruvrv.2012.101.4955
URI: 
Access Rights: 
Acesso aberto
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/133817
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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