Xavier, José Cândido Caldeira; Coelho, Kunie I. Rabello; Sassaki, Ligia; Yamashiro, Fabio da Silva; Oliveira, Kelly Christian Lima; Rodrigues, Maria Aparecida Marchesan

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/136968

Other Titles:

Primary sclerosing cholangitis associated with severe ulcerative colitis in a young man

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)

ISSN:

2236-1960

Abstract:

Primary sclerosing cholangitis, a chronic progressive cholestatic liver disease, is the most serious hepatobiliary complication of ulcerative colitis (UC). The authors present the case of a severe and intractable form of UC associated with primary sclerosing cholangitis, in which the diagnosis of this hepatobiliary complication was made during the postmortem examination. A 19-year-old man, with an 8-month diagnosis of UC, was non-responsive to any therapeutic approach. He presented at the emergency care unit severely ill and with cachexia, and subsequently died of septic shock. The postmortem examination confirmed the clinical diagnosis of severe UC and disclosed the presence of primary sclerosing cholangitis. Although laboratory tests have shown a typical cholestatic profile with elevated alkaline phosphatase and gamma-glutamyl transferase levels, hepatic dysfunction was related to sepsis. This report highlights how challenging the diagnosis of primary sclerosing cholangitis can be and shows the value of the postmortem examination to add important information to a medical diagnosis.

Issue Date:

2013

Citation:

Autopsy and Case Reports, v. 3, n. 4, p. 37-41, 2013.

Time Duration:

37-41

Keywords:

Cholangitis, Sclerosing
Colitis, Ulcerative
Autopsy

Source:

http://dx.doi.org/10.4322/acr.2013.037

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/136968

Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Show full item record View Statistics