Crystallization and preliminary X-ray diffraction studies of two myotoxic Lys49-phospholipases A(2) complexed with alpha-tocopherol

dos Santos, J. I.; Takeda, AAS; Marchi-Salvador, D. P.; Soares, A. M.; Fontes, MRM

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/17599

Title:

Crystallization and preliminary X-ray diffraction studies of two myotoxic Lys49-phospholipases A(2) complexed with alpha-tocopherol

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
UNAERP

ISSN:

0929-8665

Abstract:

BnSP-7 and BnSP-6, two Lys49-phospholipase A(2) isolated from Bothrops neuwiedi pauloensis snake venom, were co-crystallized with a-tocopherol and X-ray diffraction data were collected for both complexes (2.2 and 2.6 angstrom). A new alternative quaternary conformation for these two complexes compared with all other dimeric Lys49-PLA(2) has been observed.

Issue Date:

1-Nov-2005

Citation:

Protein and Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 12, n. 8, p. 819-822, 2005.

Time Duration:

819-822

Publisher:

Bentham Science Publ Ltd

Keywords:

crystallization
X-ray crystallography
Lys49-phospholipase A(2)
Bothrops neuwiedi venom
myotoxity
alpha-tocopherol

Source:

http://dx.doi.org/10.2174/0929866054864283

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/17599

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