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http://acervodigital.unesp.br/handle/11449/18241
- Title:
- Interleukin-10 but not Transforming Growth Factor beta inhibits murine activated macrophages Paracoccidioides brasiliensis killing: Effect on H2O2 and NO production
- Universidade Estadual Paulista (UNESP)
- 0008-8749
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- FAPESP: 00/04876-8
- Paracoccidioidomycosis is caused by the thermally dimorphic fungus Paracoccidioides brasiliensis (P brasiliensis). Most often, this mycosis runs as a chronic progressive course affecting preferentially the lungs. In vitro fungicidal activity against a high virulent strain of P brasiliensis by murine peritoneal macrophages preactivated with IFN-gamma or TNF-alpha is high and correlates with increased NO and H2O2 production. Within this context, the purpose of this work was to study the role of suppressor cytokines, such as IL-10 and TGF-beta, in this process. Incubation of either IFN-gamma or TNF-alpha with IL-10 inhibits fungicidal activity of these cells However, TGF-beta had no effect on fungicidal activity of IFN-gamma or TNF-alpha-activated macrophages. The suppression of fungicidal activity by IL-10 correlated with the inhibition of NO and H2O2 production supporting the involvement of these metabolites in P brasiliensis killing These results suggest that IL-10 production in vivo could represent an evasion mechanism of the fungus to avoid host immune response (C) 2010 Elsevier Inc All rights reserved.
- 1-Jan-2010
- Cellular Immunology. San Diego: Academic Press Inc. Elsevier B.V., v. 263, n. 2, p. 196-203, 2010.
- 196-203
- Academic Press Inc. Elsevier B.V.
- Murine paracoccidioidomycosis
- Macrophages
- Fungicidal activity
- IL-10
- TGF-beta
- NO
- H2O2
- http://dx.doi.org/10.1016/j.cellimm.2010.03.016
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/18241
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