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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/18703
Title: 
Mitochondrial DNA polymorphism and heteroplasmy in populations of Aedes aegypti in Brazil
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0022-2585
Abstract: 
The tropical mosquito Aedes aegypti (Diptera: Culicidae) is the most important domestic vector of urban yellow fever and dengue viruses. Ae. aegypti originated from Africa and was probably introduced into Brazil during the colonial period through embarkations, and dengue epidemics soon followed. Genetic analysis of 12 Ae. aegypti populations from five states in Brazil was conducted based on two mitochondrial DNA fragments: cytochrome oxidase I and NADH dehydrogenase subunit 4. Analyses comparing individual haplotypes indicated the existence of two well-defined clades, probably representing two mitochondrial lineages. Analysis of molecular variance showed significant variability in genetic structure among collections within groups. Mantel regression analysis showed a correlation between genetic and geographic distances, mainly because of northern and northeastern populations, in comparison with those in the southeast. The population from Santos, the largest port in Brazil, showed the greatest diversity, with 10 unique haplotypes, an indication of recent introductions that have not yet spread to other Brazilian cities. Different mitochondrial DNA sequences were found in three specimens, indicating the presence of heteroplasmy.
Issue Date: 
1-Jan-2008
Citation: 
Journal of Medical Entomology. Lanham: Entomological Soc Amer, v. 45, n. 1, p. 59-67, 2008.
Time Duration: 
59-67
Publisher: 
Entomological Soc Amer
Keywords: 
  • Aedes aegypti
  • population genetics
  • mitochondrial DNA
  • genetic variability
  • heteroplasmy
Source: 
http://dx.doi.org/10.1603/0022-2585(2008)45[59:MDPAHI]2.0.CO;2
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/18703
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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