Biochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A(2) from Bothrops jararacussu venom

Murakami, Mario T.; Lourenzoni, Marco R.; Arruda, Emerson Z.; Tomaz, Marcelo A.; Vicoti, Magno M.; Abrego, Jose R. B.; Melo, Paulo A.; Arni, Raghuvir K.

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/22085

Title:

Biochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A(2) from Bothrops jararacussu venom

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
LNLS
Universidade Federal do Rio de Janeiro (UFRJ)
Instituto Butantan

ISSN:

0929-8665

Sponsorship:

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
CAT/CEPID

Abstract:

Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding.

Issue Date:

1-Sep-2008

Citation:

Protein and Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 15, n. 9, p. 1002-1008, 2008.

Time Duration:

1002-1008

Publisher:

Bentham Science Publ Ltd

Keywords:

phospholipases A(2)
suramin
pharmacological activities
structural studies

Source:

http://eurekaselect.com/83229/article

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/22085

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