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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/26019
Title: 
Trypanocidal tetrahydrofuran lignans from Peperomia blanda
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Universidade de São Paulo (USP)
  • Inst Pesquisas Jardim Rio Janeiro
ISSN: 
0031-9422
Sponsorship: 
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Sponsorship Process Number: 
  • FAPESP: 03/11524-9
  • FAPESP: 05/57042-0
Abstract: 
Five tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastercomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y. (C) 2007 Elsevier Ltd. All rights reserved.
Issue Date: 
1-Jan-2008
Citation: 
Phytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 2, p. 445-450, 2008.
Time Duration: 
445-450
Publisher: 
Pergamon-Elsevier B.V. Ltd
Keywords: 
  • Peperomia blanda
  • Piperaceae
  • tetrahydrofuran lignans
  • structural elucidation
  • trypanocidal activity
Source: 
http://dx.doi.org/10.1016/j.phytochem.2007.08.012
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/26019
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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