Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga

Serrano, Maria A. R.; Pivatto, Marcos; Francisco, Welington; Danuello, Amanda; Regasini, Luis O.; Lopes, Elaine M. C.; Lopes, Márcia Nasser; Young, Maria C. M.; Bolzani, Vanderlan da Silva

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/26079

Title:

Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
Inst Bot

ISSN:

0163-3864

Sponsorship:

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Biodiversity Virtual Institute
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Sponsorship Process Number:

Biodiversity Virtual Institute: 03/02176-7

Abstract:

Two unusual pyridine alkaloids, 7'-multijuguinone (1) and 12'-hydroxy-7'-multijuguinone none (2), were isolated front the leaves of Senna multijuga, together with the known flavonoid rutin. The structures of the new alkaloids were established oil the basis of spectroscopy data interpretation. Compounds I and 2 exhibited moderate in vitro acetylcholinesterase (AChE) inhibitory activity, in comparison With the standard compound physostiomine.

Issue Date:

1-Mar-2010

Citation:

Journal of Natural Products. Washington: Amer Chemical Soc, v. 73, n. 3, p. 482-484, 2010.

Time Duration:

482-484

Publisher:

Amer Chemical Soc

Source:

http://dx.doi.org/10.1021/np900644x

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/26079

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