Cytotoxic Clerodane Diterpenes from Casearia rupestris

Vieira-Junior, Gerardo M.; Dutra, Luiz A.; Ferreira, Paulo M. P.; de Moraes, Manoel O.; Lotufo, Leticia V. Costa; Pessoa, Claudia do O.; Torres, Roseli Buzanelli; Boralle, Nivaldo; Bolzani, Vanderlan da Silva; Cavalheiro, Alberto José

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/26092

Title:

Cytotoxic Clerodane Diterpenes from Casearia rupestris

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
Universidade Federal do Piauí (UFPI)
Universidade Federal do Ceará (UFC)
Instituto Agronômico (IAC)

ISSN:

0163-3864

Sponsorship:

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Biota Instituto Virtual da Biodiversidade

Sponsorship Process Number:

FAPESP: 03/02176-7

Abstract:

Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6), All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Caseartipestrin A (1) exhibited the most potent activity against MDA/MB-435 (human Melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug:doxorubicin.

Issue Date:

1-Apr-2011

Citation:

Journal of Natural Products. Washington: Amer Chemical Soc, v. 74, n. 4, p. 776-781, 2011.

Time Duration:

776-781

Publisher:

Amer Chemical Soc

Source:

http://dx.doi.org/10.1021/np100840w

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/26092

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