Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/26167
- Title:
- Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
- Inst Bot
- Universidade Estadual Paulista (UNESP)
- Universidade de São Paulo (USP)
- 1420-3049
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- FAPESP: 03/02176-7
- Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(50) = 2.5 mu M), similar to that of the reference compound galanthamine (IC(50) = 1.7 mu M). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.
- 1-Dec-2010
- Molecules. Basel: Mdpi Ag, v. 15, n. 12, p. 9205-9213, 2010.
- 9205-9213
- Mdpi Ag
- Esenbeckia leiocarpa
- Rutaceae
- alkaloids
- acetylcholinesterase inhibitors
- http://dx.doi.org/10.3390/molecules15129205
- Acesso aberto
- outro
- http://repositorio.unesp.br/handle/11449/26167
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