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http://acervodigital.unesp.br/handle/11449/26273- Title:
- Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae)
- Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum
- Universidade Estadual Paulista (UNESP)
- Universidade Federal de Lavras (UFLA)
- Instituto de Botânica
- Universidade de São Paulo (USP)
- Universidade Estadual de Campinas (UNICAMP)
- 0100-4042
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.
- 1-Jan-2010
- Química Nova. Sociedade Brasileira de Química, v. 33, n. 10, p. 2038-2041, 2010.
- 2038-2041
- Sociedade Brasileira de Química
- Xylaria sp.
- Piper aduncum
- endophytic fungus
- http://dx.doi.org/10.1590/S0100-40422010001000006
- Acesso aberto
- outro
- http://repositorio.unesp.br/handle/11449/26273
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