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http://acervodigital.unesp.br/handle/11449/27611
- Title:
- Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
- Local anesthetics: interaction with biological membranes and with the voltage-gated sodium channel
- Universidade Estadual de Campinas (UNICAMP)
- Universidade Estadual Paulista (UNESP)
- 0100-4042
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase.
- 1-Jan-2008
- Química Nova. Sociedade Brasileira de Química, v. 31, n. 7, p. 1775-1783, 2008.
- 1775-1783
- Sociedade Brasileira de Química
- local anesthetic
- membrane
- voltage-gated sodium channel
- http://dx.doi.org/10.1590/S0100-40422008000700032
- Acesso aberto
- outro
- http://repositorio.unesp.br/handle/11449/27611
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