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http://acervodigital.unesp.br/handle/11449/32404
- Title:
- Receptor-mediated effects of clonidine on need-induced 3% NaCl and water intake
- Universidade Estadual Paulista (UNESP)
- 0361-9230
- Clonidine combined with adrenergic antagonists were injected in the medial septal area in order to characterize the type of receptors involved with its inhibitory effect on 3% NaCl and water intake of sodium-depleted (furosemide + 24 h of removal of ambient sodium) and 30-h water-deprived rats, respectively. The inhibitory effect of clonidine (20 nmol) on need-induced water intake was reduced 50% by an 80-nmol dose of either idazoxan, yohimbine or prazosin. The inhibitory effect of clonidine (30 nmol) on need-induced 3% NaCl intake was completely antagonized by idazoxan (80, 160 nmol), not altered by yohimbine (40-160 nmol), and partially potentiated (40 nmol) or inhibited (160 nmol) by prazosin. Propranolol did not alter the effects of clonidine on either water (80 nmol) or 3% NaCl (40-160 nmol) intake. The results suggest that the inhibitory effects of clonidine on 3% NaCl and water intake are mediated by different types of alpha2-adrenergic receptors. Copyright (C) 1997 Elsevier B.V.
- 1-Jan-1997
- Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 42, n. 3, p. 205-209, 1997.
- 205-209
- Elsevier B.V.
- adrenergic receptors
- clonidine
- noradrenaline
- salt intake
- water intake
- drinking
- http://dx.doi.org/10.1016/S0361-9230(96)00257-2
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/32404
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