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http://acervodigital.unesp.br/handle/11449/32593
- Title:
- Differential effects of novel wasp toxin on rat hippocampal interneurons
- Jichi Med Sch
- Natl Inst Physiol Sci
- Universidade Estadual Paulista (UNESP)
- 0304-3940
- We studied the effects of a wasp toxin beta-pompilidotoxin (beta-PMTX) on rat hippocampal CA1 interneurons by the current-clamp technique. The firing patterns of pyramidal neurons and pyramidale interneurons were not affected by beta-PMTX, but in oriens and radiatum interneurons, beta-PMTX converted the action potentials to prolonged depolarizing potentials by slowing the inactivation of Na+ channels. In lacunosum moleculare interneurons, beta-PMTX induced initial bursting spikes followed by block of succeeding spikes. Comparison of beta-PMTX with a sea anemone toxin, ATX 11, revealed that ATX 11 altered the firing properties of pyramidal neurons and pyramidale interneurons that were unchanged by beta-PMTX. Our results suggest that beta-PMTX modulates Na+ currents in CAl interneurons differently in various CAl neurons and the toxin is useful to classify Na+ channel subtypes. (C) 2002 Elsevier B.V. Ireland Ltd. All rights reserved.
- 2-Aug-2002
- Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 328, n. 1, p. 25-28, 2002.
- 25-28
- Elsevier B.V.
- interneuron
- sodium channel
- inactivation
- wasp toxin
- pompilidotoxin
- sea anemone toxin
- http://dx.doi.org/10.1016/S0304-3940(02)00432-9
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/32593
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