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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/32929
Título: 
Flow injection amperometric determination of procaine in pharmaceutical formulation using a screen-printed carbon electrode
Autor(es): 
Instituição: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0731-7085
Resumo: 
A rapid and simple method for procaine determination was developed by flow injection analysis (FIA) using a screen-printed carbon electrode (SPCE) as amperometric detector. The present method is based on the amine/hydroxylamine oxidation from procaine monitored at 0.80 V on SPCE in sodium acetate solution pH 6.0. Using the best experimental conditions assigned as: pH 6.0, flow rate of 3.8 mL min(-1), sample volume of 100 mu L and analytical path of 30 cm it is possible to construct a linear calibration curve from 9.0 x 10(-6) to 1.0 x 10(-4) mol L-1. The relative standard deviation for 5.0 x 10(-5) mol L-1 procaine (15 repetitions using the same electrode) is 3.2% and detection limit calculated is 6.0 x 10(-6) mol L-1. Recoveries obtained for procaine gave a mean values from 94.8 to 102.3% and an analytical frequency of 36 injections per hour was achieved. The method was successfully applied for the determination of procaine in pharmaceutical formulation without any pre-treatment, which are in good accordance with the declared values of manufacturer and an official method based on spectrophotometric analysis. (c) 2006 Elsevier B.V. All rights reserved.
Data de publicação: 
4-Jan-2007
Citação: 
Journal of Pharmaceutical and Biomedical Analysis. Oxford: Pergamon-Elsevier B.V., v. 43, n. 1, p. 315-319, 2007.
Duração: 
315-319
Publicador: 
Elsevier B.V.
Palavras-chaves: 
  • procaine
  • FIA amperometric
  • screen-printed carbon electrode
Fonte: 
http://dx.doi.org/10.1016/j.jpba.2006.06.001
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/32929
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