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http://acervodigital.unesp.br/handle/11449/336- Title:
- Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella
- Universidade Estadual Paulista (UNESP)
- Univ Presbiteriana Mackenzie
- Universidade Federal do Ceará (UFC)
- Universidade Federal do Rio de Janeiro (UFRJ)
- Universidade Estadual de Campinas (UNICAMP)
- UFC
- 1572-3887
- FAPEPS
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- FAPEPS: 54714-3
- CNPq: 558193/2009-9
- Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.
- 1-Nov-2010
- Protein Journal. New York: Springer, v. 29, n. 8, p. 567-571, 2010.
- 567-571
- Springer
- Botryocladia occidentalis
- Crotalus durissus cascavella
- Secretory phospholipase A2 (sPLA2)
- Edema
- Myonecrosis
- http://dx.doi.org/10.1007/s10930-010-9294-9
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/336
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