You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/33949
Title: 
Effect of age on the gastrointestinal-associated mucosal immune response of humans
Author(s): 
Institution: 
  • Tufts Univ
  • Universidade Estadual Paulista (UNESP)
ISSN: 
1079-5006
Abstract: 
Age-related changes in gastrointestinal-associated mucosal immune response have not been well studied. Thus, we investigated the effect of age on this response and compared these responses to those of peripheral immune cells. Saliva, blood, and intestinal biopsies were collected from young and old healthy subjects to determine immunoglobulin (Ig) levels and to isolate peripheral blood mononuclear cells, intraepithelial lymphocytes (IELs), and lamina propria lymphocytes (LPLs). Although subject age did not influence the level of total IgA found in saliva, IgA levels in serum increased (p < .05) with age. Older subjects' peripheral blood mononuclear cell proliferation and IL-2 production were significantly lower than those of young subjects. LPLs from older subjects produced significantly less IL-2 in response to all stimuli than did that from the young. IEL's ability to proliferate and produce IL-2 was not affected by subject age. Thus, LPL but not IEL demonstrated an age-related decline in immune function similar to that seen in peripheral lymphocytes.
Issue Date: 
1-May-2001
Citation: 
Journals of Gerontology Series A-biological Sciences and Medical Sciences. Washington: Gerontological Society Amer, v. 56, n. 5, p. B218-B223, 2001.
Time Duration: 
B218-B223
Publisher: 
Gerontological Society Amer
Source: 
http://www.ncbi.nlm.nih.gov/pubmed/11320102
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/33949
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.