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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/35833
Title: 
Relative contributions of beta-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia
Author(s): 
Institution: 
  • Univ Utrecht
  • Universidade Estadual Paulista (UNESP)
  • Univ Athens
  • Univ Pittsburgh
  • Univ Oslo
  • Univ Helsinki
  • University of Rochester
ISSN: 
0026-0495
Abstract: 
We performed hyperglycemic clamps in 283 nondiabetic Caucasians and, with multiple linear regression, determined the contribution of beta-cell function and tissue insulin sensitivity to variations in glycemia and insulinemia during oral glucose tolerance tests (OGTTs). Impaired glucose tolerance (IGT) subjects had reduced insulin sensitivity(P < .02) and beta-cell function (P < .0001). Normal glucose tolerance (NGT) subjects with first-degree type 2 diabetic relatives had reduced first and second phase insulin secretion (both, P < .05), but normal insulin sensitivity(P = .37). beta-Cell function and insulin sensitivity accounted for one fourth of the variability in glucose tolerance. Fasting plasma glucose in subjects with NGT (n = 185) was a function of both phases of insulin secretion and of insulin sensitivity tall, P < .05), whereas, in IGT subjects (n = 98), it was a function of first phase insulin secretion and insulin sensitivity(P < .01). Two-hour glycemia was a function of second phase secretion and insulin sensitivity (P < .01). Fasting and 2-hour plasma insulin levels were determined by insulin sensitivity land glycemia) in NGT subjects (P < .001), but by second phase secretion in IGT (P < .001). We conclude that beta-cell function is reduced in subjects with IGT; glycemia and insulinemia are not regulated by the same mechanisms in IGT and NGT; insulin sensitivity does not contribute to insulinemia in IGT; family history of diabetes influences beta-cell function, but not insulin sensitivity in Caucasians. Copyright (C) 2000 by W.B. Saunders Company.
Issue Date: 
1-Oct-2000
Citation: 
Metabolism-clinical and Experimental. Philadelphia: W B Saunders Co, v. 49, n. 10, p. 1318-1325, 2000.
Time Duration: 
1318-1325
Publisher: 
W B Saunders Co
Source: 
http://dx.doi.org/10.1053/meta.2000.9526
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/35833
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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