You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/36827
Title: 
Bombesin affects the central nervous system to produce sodium intake inhibition in rats
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • UNIV IOWA
ISSN: 
0031-9384
Abstract: 
Bombesin (BN) elicits in the rat important behavioural modifications, including inhibition of food and of water intake. Recently, it has been observed that the peptide also inhibits the intake of sodium chloride. To stare whether BN possesses a selective antinatriorexic effect or it elicits only an aspecific depression of ingestive behaviour, we studied the effects of this peptide on the intake of sodium, water or sucrose of Wistar rats after injections into the fourth brain ventricle or into selected brain areas involved in the control of sodium intake, containing BN-like peptides and/or their precursors or specific receptors. We observed that: a) BN (100-200 ng/rat) injected into the fourth brain ventricle inhibits not only the intake of 2% NaCl of sodium depleted rats but also that of water and of 5% sucrose; b) BN (5-50 ng/rat) administered into the nucleus of the solitary tract and the medial amygdala does not influence the intake of these fluids and c) BN (5-50 ng/rat) injected into the paraventricular nucleus does not influence the intake of water and 5% sucrose but potently inhibits that of 2% NaCl. We concluded that the inhibitory effect elicited on salt intake by intracranial administration of BN is selective for this behaviour and is not the expression of an aspecific depression of ingestive behaviour. (C) 1998 Elsevier B.V.
Issue Date: 
31-Dec-1997
Citation: 
Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 63, n. 1, p. 15-23, 1997.
Time Duration: 
15-23
Publisher: 
Elsevier B.V.
Keywords: 
  • bombesin
  • sodium appetite
  • nucleus of the solitary tract
  • medial amygdala
  • paraventricular nucleus
Source: 
http://dx.doi.org/10.1016/S0031-9384(97)00380-6
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/36827
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.