Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom

Murakami, M. T.; Gava, L. M.; Zela, S. P.; Arruda, E. Z.; Melo, P. A.; Gutierrez, J. M.; Arni, R. K.

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/37254

Title:

Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Univ Costa Rica

ISSN:

1570-9639

Abstract:

Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA(2) from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 degreesC. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a=49.05, b=63.84 and c=85.67 Angstrom, Diffraction data was collected to 1.78 Angstrom. (C) 2004 Elsevier B.V. All rights reserved.

Issue Date:

1-Dec-2004

Citation:

Biochimica Et Biophysica Acta-proteins and Proteomics. Amsterdam: Elsevier B.V., v. 1703, n. 1, p. 83-85, 2004.

Time Duration:

83-85

Publisher:

Elsevier B.V.

Keywords:

suramin
myotoxicity
snake venom
Lys49 PLA(2)s
X-ray diffraction

Source:

http://dx.doi.org/10.1016/j.bbapap.2004.08.009

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/37254

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