Calcium-Independent Membrane Damage by Venom Phospholipases A(2)

de Oliveira, A. H. C.; Aragao, E. A.; Sa, J. M.; Chioato, L.; Bugs-Bortoleto, R.; Ruller, R.; Ferreira, T. L.; Ward, R. J.

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/39745

Title:

Calcium-Independent Membrane Damage by Venom Phospholipases A(2)

Author(s):

Institution:

Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)

ISSN:

0929-8665

Sponsorship:

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (FAEPA)
PRP-USP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Abstract:

Many snake venom phospholipase A(2)s (vPLA(2)s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA(2)s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.

Issue Date:

1-Aug-2009

Citation:

Protein and Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 16, n. 8, p. 877-886, 2009.

Time Duration:

877-886

Publisher:

Bentham Science Publ Ltd

Keywords:

Membrane permeabilization
molecular mechanism
micelle nucleation

Source:

http://eurekaselect.com/84727/article

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/39745

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