Lithium thiazolidine-4-carboxylate: Synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cells

Abstract

A new water-soluble lithium Salt of thiazolidine-4-carboxylic acid was synthesized and characterized by chemical and spectroscopic techniques, Elemental and mass spectrometric (ESI-MS) analyses of the solid compound fit to the composition LiC(4)H(6)NSO(2). (1)H, (13)C nuclear magnetic resonance (NMR). [(1)H-(15)N] NMR and infrared (IR) analyses permitted to elucidate the structure of the compound. Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium Salt colorimetric assay, which reflects the cells viability. (C) 2008 Elsevier B.V. All rights reserved.