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http://acervodigital.unesp.br/handle/11449/42157
- Title:
- Characterization and biological studies of a new platinum(II) complex with the amino acid L-alliin
- Universidade Estadual Paulista (UNESP)
- Universidade de São Paulo (USP)
- 0095-8972
- Synthesis and characterization of a new Pt(II) complex with the amino acid L-alliin (S-allyl-L-cysteine sulfoxide, C(6)H(11)NO(3)S) are described. Elemental and mass spectrometric analyses of the solid complex are consistent with [PtCl(2)(alliin)], or [PtCl(2)(C(6)H(11)NO(3)S)]. (13)C nuclear magnetic resonance (NMR), [(1)H-(15)N] two dimensional (2D) NMR and infrared spectroscopy indicate coordination of the ligand to Pt(II) through the N and S atoms. The complex is very soluble in dimethyl sulfoxide. Biological analysis for evaluation of a potential cytotoxic effect of the complex was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented moderate cytotoxic activity, inducing about 40% cell death at a concentration of 400 mol L(-1).
- 1-Jan-2008
- Journal of Coordination Chemistry. Abingdon: Taylor & Francis Ltd, v. 61, n. 15, p. 2470-2477, 2008.
- 2470-2477
- Taylor & Francis Ltd
- S-allyl-L-cysteine sulfoxide
- L-alliin
- platinum(II)
- (15)N resonance
- cytotoxicity
- http://dx.doi.org/10.1080/00958970801930005
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/42157
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