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http://acervodigital.unesp.br/handle/11449/66692
- Title:
- Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo
- Locus ABO (9q 34.1) genotyping in blood donors in the state of Sao Paulo, Brazil
- Faculdade de Medicina de São José do Rio Preto (FAMERP)
- Universidade Estadual Paulista (UNESP)
- 1516-8484
- The advances of molecular genetics enabled us to understand the molecular basis of the ABO locus. Considering Us importance as a genetic marker and its applications, the aim of this study was to verify the distribution of the ABO genotypes in a Brazilian population from the Northwest region of the Sào Paulo Stale, Brazil. The genomic DNA was extracted from three hundred and twenty four healthy Brazilian blood donors (O ] 50; A 118; B 32 and AB 24) and analyzed by PCR amplification followed by restriction enzyme digestion. Fourteen genotypes were identified and the relative frequencies of the O , O , O , A and B genes ivere estimated at 44.6%, 16.9%, 4.1%, 25.3% and 9.1%, respectively. Tloese results demonstrate that the ABO locus presents a high polymorphism as revealed by molecular analysis.
- 1-Dec-2001
- Revista Brasileira de Hematologia e Hemoterapia, v. 23, n. 1, p. 15-22, 2001.
- 15-22
- ABO genes
- ABO genotypes
- Blood donors
- http://dx.doi.org/10.1590/S1516-84842001000100003
- Acesso aberto
- outro
- http://repositorio.unesp.br/handle/11449/66692
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