Synthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective SNAr reactions

Goncalves, Renato S.; Abdelnur, Patricia V.; Santos, Vanessa G.; Simas, Rosineide C.; Eberlin, Marcos N.; Magalhaes, Alvicler; Perez Gonzalez, Eduardo R.

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/6863

Title:

Synthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective SNAr reactions

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
Universidade Estadual de Campinas (UNICAMP)

ISSN:

0939-4451

Abstract:

Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by SNAr reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-elimination SNAr mechanism was confirmed by NMR and MS measurements.

Issue Date:

1-Jan-2011

Citation:

Amino Acids. New York: Springer, v. 40, n. 1, p. 197-204, 2011.

Time Duration:

197-204

Publisher:

Springer

Keywords:

PABA derivatives
Lactams
Potential bio-activity
SNAr reaction

Source:

http://dx.doi.org/10.1007/s00726-010-0634-z

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/6863

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