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http://acervodigital.unesp.br/handle/11449/68864- Title:
- Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
- Universidade Estadual Paulista (UNESP)
- Facultad de Microbiologia
- Universidad de Costa Rica
- Instituto Butantan
- 1744-3091
- Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 Å resolution and the anion-binding site has been characterized. © 2006 International Union of Crystallography. All rights reserved.
- 1-May-2006
- Acta Crystallographica Section F: Structural Biology and Crystallization Communications, v. 62, n. 5, p. 423-426, 2006.
- 423-426
- Atropoides nummifer
- myotoxin II, Atropoides nummifer
- phospholipase A
- snake venom
- amino acid sequence
- binding site
- chemistry
- crystallization
- molecular genetics
- sequence alignment
- X ray crystallography
- Amino Acid Sequence
- Binding Sites
- Crotalid Venoms
- Crystallization
- Crystallography, X-Ray
- Molecular Sequence Data
- Phospholipases A
- Sequence Alignment
- http://dx.doi.org/10.1107/S1744309106010700
- http://www.ncbi.nlm.nih.gov/pubmed/16682766
- Acesso aberto
- outro
- http://repositorio.unesp.br/handle/11449/68864
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