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http://acervodigital.unesp.br/handle/11449/69512- Title:
- Amphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compounds
- Instituto Adolfo Lutz (IAL)
- Instituto Butantan
- Universidade Estadual Paulista (UNESP)
- 1570-1808
- The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases. © 2007 Bentham Science Publishers Ltd.
- 10-Jan-2007
- Letters in Drug Design and Discovery, v. 4, n. 1, p. 67-73, 2007.
- 67-73
- Amphibians
- Antimicrobial
- Leishmania
- Peptides
- Secretions
- Trypanosoma
- amino acid oxidase
- amphibian protein
- antifungal agent
- antiparasitic agent
- benznidazole
- meglumine antimonate
- pentamidine
- pyrimethamine
- Amphibia
- animal cell
- animal experiment
- animal model
- animal tissue
- Candida
- controlled study
- dose response
- drug design
- drug effect
- drug research
- enzyme activity
- growth inhibition
- mouse
- nonhuman
- priority journal
- skin secretion
- http://dx.doi.org/10.2174/157018007778992856
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/69512
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